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《医学前沿(英文)》 doi: 10.1007/s11684-023-0999-5
关键词: thyroid carcinoma mesenchymal stem cell extracellular vesicle GTF2I FAT1 CDK4
null
《医学前沿(英文)》 2016年 第10卷 第1期 页码 76-84 doi: 10.1007/s11684-015-0426-7
Anti-β2 glycoprotein I (anti-β2GP I ) antibodies are important contributors to thrombosis, especially in patients with antiphospholipid syndrome (APS). However, the mechanism by which anti-β2GP I antibodies are involved in the pathogenesis of thrombosis is not fully understood. In this report, we investigated the role of anti-β2GP I antibodies in complexes with β2GP I as mediators of platelet activation, which can serve as a potential source contributing to thrombosis. We examined the involvement of the apolipoprotein E receptor 2' (apoER2') and glycoprotein I ba (GP I bα) in platelet activation induced by the anti-β2GP I /β2GP I complex. The interaction between the anti-β2GP I /β2GP I complex and platelets was examined using in vitro methods, in which the Fc portion of the antibody was immobilized using protein A coated onto a microtiter plate. Platelet activation was assessed by measuring GP II b/ III a activation and P-selectin expression and thromboxane B2 production as well as p38 mitogen-activated protein kinase phosphorylation. Our results revealed that the anti-β2GP I /β2GP I complex was able to activate platelets, and this activation was inhibited by either the anti-GP I bα antibody or the apoER2' inhibitor. Results showed that the anti-β2GP I /β2GP I complex induced platelet activation via GP I bα and apoER2', which may then contribute to the prothrombotic tendency in APS patients.
关键词: anti-β2GP I /β2GP I complex platelet GP I bα apoER2' thrombosis
SARS-CoV-2 侵入因子——<i>ACE2i> 和<i>TMPRSS2i> 在围着床期胚胎和母胎界面存在表达 Article
陈伟,袁鹏,杨铭,严智强,孔思明,严杰,柳溪溪,陈依东,乔杰,闫丽盈
《工程(英文)》 2020年 第6卷 第10期 页码 1162-1169 doi: 10.1016/j.eng.2020.07.013
在全球肆虐的严重急性呼吸系统综合征冠状病毒2(severe acute respiratory syndrome coronavirus 2,SARS-CoV-2)导致了大量人群感染,血管紧张素转化酶2(angiotensin-converting enzyme 2, ACE2)是SARS-CoV和SARS-CoV-2的受体蛋白。然而是否存在SARS-CoV-2的垂直传播仍颇有争议。为了探讨SARS-CoV-2垂直传播的潜在风险,我们利用已发表的单细胞转录组数据观察了围着床期胚胎和母胎界面上ACE2和TMPRSS2(编码跨膜丝氨酸蛋白酶2)的转录表达情况ACE2阳性表达的STB细胞中存在明显的性别差异。
关键词: SARS-CoV-2 ACE2 垂直传播 胎盘 围着床期
H2 对Pt-Ba-Ce /γ-Al2O3 催化剂NO<i>xi> 存储和还原机理的影响研究 Article
王攀, 裔静, 孙川, 罗鹏, 雷利利
《工程(英文)》 2019年 第5卷 第3期 页码 568-575 doi: 10.1016/j.eng.2019.02.005
本研究采用浸渍法制备了Pt-Ba-Ce/γ-Al2O3催化剂,利用实验评价了H2 对NSR(NOx storage and reduction)催化剂存储和还原机理的影响,并采用综合表征技术研究了Pt-Ba-Ce /γ-Al2O3x、CeO2 和BaCO3 峰很好地分散在γ-Al2O3 上,X 射线光电子能谱(XPS)检测到Ce3+ 和Ce4+ 之间的差异,Ce3+ 和Ce4+ 促进了活性氧在催化剂上的迁移。适当增加H2量加速了硝酸盐或亚硝酸盐的分解,有利于NOx 存储-还原,并促进了下一循环NSR吸附位点的再生。
关键词: Pt–Ba–Ce/γ-Al2O3 催化剂,物理化学性质,NO<i>xi>存储和还原,NO<i>xi> 排放,H2 还原剂
<i>RR1i> and <i>RR2i> gene deletion affects the immunogenicity of a live attenuated pseudorabies
Shijun YAN,He YAN,Chaolin ZHANG,Tongyan WANG,Qingyuan YANG,Zhe SUN,Yan XIAO,Feifei TAN,Xiangdong LI,Kegong TIAN
《农业科学与工程前沿(英文)》 2016年 第3卷 第1期 页码 81-86 doi: 10.15302/J-FASE-2016088
关键词: pseudorabies virus RR1 and RR2 ribonucleotide reductase vaccine candidate
NO<i>xi> and H2S formation in the reductive zone of air-staged combustion of
Jinzhi CAI, Dan LI, Denggao CHEN, Zhenshan LI
《能源前沿(英文)》 2021年 第15卷 第1期 页码 4-13 doi: 10.1007/s11708-020-0804-y
关键词: blended coal combustion NOx formation H2S formation air staged combustion
Yan Shi, Fangjun Huo, Yongkang Yue, Caixia Yin
《化学科学与工程前沿(英文)》 2022年 第16卷 第1期 页码 64-71 doi: 10.1007/s11705-021-2048-8
关键词: heterocyclic compound hydrogen sulfide ratiometric mitochondrial targeted
><i>In situi> growth of phosphorized ZIF-67-derived amorphous CoP/Cu2O@CF electrocatalyst
《化学科学与工程前沿(英文)》 2023年 第17卷 第10期 页码 1430-1439 doi: 10.1007/s11705-023-2320-1
富含<i>sni>-2 DHA脂质对大脑的益处及其酶法合成综述 Review
金俊, 金青哲, 王兴国, Casimir C. Akoh
《工程(英文)》 2020年 第6卷 第4期 页码 424-431 doi: 10.1016/j.eng.2020.02.009
《能源前沿(英文)》 2022年 第16卷 第3期 页码 471-482 doi: 10.1007/s11708-021-0778-4
关键词: composite construction distribution BiO2–x evolution of defects
Yingdan Zhang, Na Liu, Wei Wang, Jianteng Sun, Lizhong Zhu
《环境科学与工程前沿(英文)》 2020年 第14卷 第6期 doi: 10.1007/s11783-020-1282-5
关键词: Nano-TiO2 Rice Photosynthesis Metabolomics Energy storage
酶法合成<i>sni>-2棕榈酸甘油酯的研究进展 Review
韦伟, 孙聪, 王小三, 金青哲, Xuebing Xu, Casimir C. Akoh, 王兴国
《工程(英文)》 2020年 第6卷 第4期 页码 406-414 doi: 10.1016/j.eng.2020.02.008
Association of gene variants with juvenile amyotrophic lateral sclerosis
《医学前沿(英文)》 doi: 10.1007/s11684-023-1005-y
关键词: TRMT2B amyotrophic lateral sclerosis mitochondrial complex I tRNA methylation reactive oxygen species
Penetrance estimation of variants in paroxysmal kinesigenic dyskinesia and infantile convulsions
《医学前沿(英文)》 2021年 第15卷 第6期 页码 877-886 doi: 10.1007/s11684-021-0863-4
关键词: penetrance PRRT2 paroxysmal kinesigenic dyskinesia infantile convulsions
用高光谱发光法研究Cu(In<i>xi>,Ga1–<i>xi>)Se2 (CIGS)模块中由P1引起的功率损耗的成因 Article
César Omar Ramírez Quiroz, Laura-Isabelle Dion-Bertrand, Christoph J. Brabec, Joachim Müller, Kay Orgassa
《工程(英文)》 2020年 第6卷 第12期 页码 1395-1402 doi: 10.1016/j.eng.2019.12.019
关键词: Cu(Inx Ga1–x)Se2 电池到模块的效率差距 由P1引起的功率损耗 高光谱光致发光 激光烧蚀短程热效应
标题 作者 时间 类型 操作
Extracellular vesicle-carried GTF2I from mesenchymal stem cells promotes the expression of tumor-suppressive
期刊论文
Anti-β glycoprotein I antibodies in complex with β2 glycoprotein I induce platelet activation via tworeceptors: apolipoprotein E receptor 2' and glycoprotein I bα
null
期刊论文
<i>RR1i> and <i>RR2i> gene deletion affects the immunogenicity of a live attenuated pseudorabies
Shijun YAN,He YAN,Chaolin ZHANG,Tongyan WANG,Qingyuan YANG,Zhe SUN,Yan XIAO,Feifei TAN,Xiangdong LI,Kegong TIAN
期刊论文
NO<i>xi> and H2S formation in the reductive zone of air-staged combustion of
Jinzhi CAI, Dan LI, Denggao CHEN, Zhenshan LI
期刊论文
<i>Ni>-Positive ion activated rapid addition and mitochondrial targeting ratiometric fluorescent probesfor <i>in vivoi> cell H2S imaging
Yan Shi, Fangjun Huo, Yongkang Yue, Caixia Yin
期刊论文
photocatalytic performance through the evolution of the properties due to the phase transition from NaBiO·2HO
期刊论文
Photosynthesis and related metabolic mechanism of promoted rice (<i>Oryza sativai> L.) growth by TiO2 nanoparticles
Yingdan Zhang, Na Liu, Wei Wang, Jianteng Sun, Lizhong Zhu
期刊论文
Penetrance estimation of variants in paroxysmal kinesigenic dyskinesia and infantile convulsions
期刊论文